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- xii, 558 p. : ill.
Cote : WM 140 C568n 2003

Maladies mentales - Étiologie ; Schizophrénie - Physiopathologie ; Schizophrénie - Étiologie ; Neurologie du développement ; Psychopathologie

This volume presents a burgeoning perspective on the origins of psychopathology , one that focuses on the development of the human central nervous systems. The contemporary neurodevelopmental perspective assumes that mental dosorders result from etiologic factors that alter the normal course of brain development. Defined here in its broadest sense, neurodevelopmetn is process that begins at conception and extends throughout the lifespan. We now know that it is a complex process and that its course can be altered by a host of factors, ranging from inherited genetic liabilities to psychosocial stressors.
This book features the very best, cutting-edge thinking in the coverging fields of developmental window represented is broad, extending from the rpenatal period through adulthood, and the authors cover a broad range of etiologic factors and a spectrum of clinical disorders. Moreover, the contributors do not hesitate to use the opportunity to hypothesize about underlying mechanisms and to speculate on future research directions.

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- xii, 278 p. : ill.
Cote : WM 203 W732m 2006

Schizophrénie ; Neuropsychiatrie ; Schizophrénie - Diagnostic ; Schizophrénie - Étiologie ; Cerveau - Physiopathologie ; Cerveau - Chimie

Over the last two decades, molecular genetics and brain imaging have guided efforts to find the causes of schizophrenia. It is becoming increasingly clear that many genes are involved in schizophrenia and that they interact with other factors in very complex ways, which have not yet been elucidated. Neuroimaging techniques have allowed scientists and physicians to examine brain structure, function, and chemistry in living patients with schizophrenia but results so far have been disappointing. No two patients seem to share exactly the same combination of clinical symptoms or physical findings. Yet all have the syndrome recognized as schizophrenia. The author of this accessible, well-written book argues that it is time to set aside the search for a single cause of schizophrenia and focus on the disease's final common pathway. He highlights clues from a wide range of research, including neurotransmitter, psychophysiological, and brain imaging studies. He then describes possibilities for the final common pathway at an understandable level in the context of what is already known about schizophrenia. While there are no preferred models of schizophrenia, a pattern is emerging which implicates those structures in the brain known to be important in integrating perception, cognition, and affect. A better understanding of these processes will be critical for developing more effective treatments. This book will help advance that effort. It will be of great value to psychiatrists, psychologists, neurologists, neuroimagers, and basic scientists working in the field of schizophrenia research, and to their students and trainees. It will also be of interest to clinicians and scientists concerned with other neuropsychiatric disorders, and to the families of those diagnosed with schizophrenia.

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- xvii, 222 p.
Cote : WM 203 H323w 2003

Schizophrénie - Étiologie ; Schizophrénie chez l'adolescent ; Psychoses chez l'adolescent ; Troubles du développement

Governments around the world have given priority to "early intervention", i.e. the early diagnosis and treatment of young adults with psychotic symptoms.
One of the main problems with this approach, is that only a small proportion of these young adults can be expected to go on to develop schizophrenia, yet all the treatment regimes are derived from work with adults who have had full psychotic episodes.

Why Does Schizophrenia Develop at Late Adolescence? proposes a controversial new model of how schizophrenia develops in late adolescence and presents clinical material aimed at influencing the way psychosis is treated, building on a state-of-the-art reassessment of the field.

• A major reconceptualisation of how schizophrenia develops
• A controversial approach
• Early intervention programmes are now extremely widespread, so there is much interest in the area and how best to treat this serious psychotic disorder

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