Auteur : Strachan, Tom / Read, Andrew

Édition : 4th edition

Maison d'édition : Garland Science

Date de publication : 2011

Collation : xxv, 781 p. : ill.

ISBN : 9780815341499

Notes : 2e p. de couv. : Quick reference -- The genetic code -- One-letter codes for amino acids
3e de couv. : Banding patterns of human chromosomes

Langue : Anglais

Table des matières : 1. Nucleic acid structure and gene expression -- 2. Chromosome structure and function -- 3. Genes in pedigrees and populations -- 4. Cells and cell-cell communication -- 5. Principles of development -- 6. Amplifying DNA : cell-based DNA cloning and PCR -- 7. Nucleic acid hybridization : principles and applications -- 8. Analyzing the structure and expression of genes and genomes -- 9. Organization of the human genome -- 10. Model organisms, comparative genomics and evolution -- 11. Human gene expression -- 12. Studying gene function in the post-genome era -- 13. Human genetic variability and its consequences -- 14. Genetic mapping of mendelian characters -- 15. Mapping genes conferring susceptibility to complex diseases -- 16. Identifying human disease genes and susceptibility factors -- 17. Cancer genetics -- 18. Genetic testing of individuals -- 19. Pharmacogenetics, personalized medicine and population screening -- 20. Genetic manipulation of animals for modeling disease and investigating gene function -- 21. Genetic approaches to treating disease

Résumé : Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject.

The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.

Mots-clés : Génétique moléculaire humaine / Génome humain / Biologie moléculaire

Cote : QH 431 S894h 2011