Auteur : Saad, Fred / Eisenberger, Mario A.

Maison d'édition : Humana Press

Date de publication : 2014

Collation : xvi, 337 p. : ill.

Collection : Currrent Clinical Urology

ISBN : 9781493911752

Langue : Anglais

Table des matières : 1.Introduction : Castration resistant prostate cancer : a rapidly expanding clinical state and a model for new therapeutic opportunities -- 2. Evolution of clinical states and the castration resistant clinical paradigm -- 3. Molecular mechanisms of prostate cancer progression after castration -- 4. New imaging modalities -- 5. Androgen receptor biology in castration resistant prostate cancer -- 6. The androgen receptor as a therapeutic target for castration-resistant prostate cancer -- 7. Approaches targeting androgen synthesis (CYP17 inhibitors) -- 8. Cytotoxic chemotherapy (Taxanes and taxane combinations) -- 9. The emerging role of immunotherapy in castrate-resistant prostate cancer -- 10. Bone-targeted therapy : rationale and current status -- 11. Radium-223 and other radiopharmaceuticals in prostate cancer -- 12. New drug development : clinical trials design in CRPC -- 13. Phase I-II targeted treatments -- 14. Defining clinical endpoints in castration-resistant prostate cancer --15. Angiogenesis inhibition in castration-resistant prostate cancer -- 16. Co-targeting adaptive survival pathways -- 17. Targeting the P13K/AKT/mTOR pathway -- 18. PARP inhibitors -- 19. Targeting C-Met/VEGF in castration resistant prostate cancer -- 20. Epigenetics in castration resistant prostate cancer -- 21. Undifferentiated prostate cancer and the neuroendocrine phenotype -- 22. Strategic addressing quality of life : management of patient-reported outcomes and symptoms -- 23. Evidence-based therapeutic approaches for mCRPC patients : rational sequence of standard treatment options and design for future drug development

Résumé : This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in depth review of proven therapeutic options, including bone targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigations are also reviewed. The text provides up to date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence based medicine.

As a concise yet comprehensive summary of the current status of the field, Management of Castration Resistant Prostate Cancer serves as a very useful resource for physicians and researchers dealing with this challenging malignancy.

Mots-clés : Prostate - Cancer / Prostate - Cancer - Traitement

Cote : WJ 762 M266 2014