Auteur : Nurnberger, John I. / Berrettini, Wade H.

Maison d'édition : Cambridge University Press

Date de publication : 2012

Collation : xii, 402 p. : ill.

ISBN : 9780521896498

Langue : Anglais

Table des matières : 1. Contribution of genetic epidemiology to our understanding of psychiatric disorders -- 2. A basic overview of contemporary human genetic analysis strategies -- 3. DNA methods -- 4. In silico analysis strategies and resources for psychiatric genetics research -- 5. Gene expression studies in psychiatric disorders -- 6. Pharmacogenetics in psychiatry -- 7. Functional validation of candidate genetic susceptibility factors for major mental illnesses -- 8. Epigenetic mechanisms in drug addiction and depression -- 9. Panic disorder -- 10. The genetics of the phobic disorders and generalized anxiety disorder -- 11. Genetic contributions to obsessive-compulsive disorder (OCD) and OCD-related disorders -- 12. Post-traumatic stress disorder -- 13. Antisocial behavior : gene-environment interplay -- 14. Learning disabilities -- 15. Attention-deficit hyperactivity disorder -- 16. Autism and autism spectrum disorders -- 17. The genetics of bipolar disorder -- 18. The genetics of major depression -- 19. The genetics of schizophrenia -- 20. The genetics of anorexia and bulimia nervosa -- 21. Genetics and common human obesity -- 22. Alcoholism -- 23. Nicotine dependence -- 24. Human molecular genetics of opioid addiction -- 25. Genetics of stimulant dependence -- 26. Genetics of personality disorders -- 27. Ethical issues in behavioral genetics -- 28. Gentics of Tourette syndrome and related disorders -- 29. Endophenotypes in psychiatric genetics -- 30. Developmental disorders -- 31. Alzheimer's disease

Résumé : Disorders of behavior represent some of the most common and disabling diseases affecting humankind; however, despite their worldwide distribution, genetic influences on these illnesses are often overlooked by families and mental health professionals. Psychiatric genetics is a rapidly advancing field, elucidating the varied roles of specific genes and their interactions in brain development and dysregulation. Principles of Psychiatric Genetics includes 22 disorder-based chapters covering, amongst other conditions, schizophrenia, mood disorders, anxiety disorders, Alzheimer's disease, learning and developmental disorders, eating disorders and personality disorders. Supporting chapters focus on issues of genetic epidemiology, molecular and statistical methods, pharmacogenetics, epigenetics, gene expression studies, online genetic databases and ethical issues. Written by an international team of contributors, and fully updated with the latest results from genome-wide association studies, this comprehensive text is an indispensable reference for psychiatrists, neurologists, psychologists and anyone involved in psychiatric genetic studies.

Mots-clés : Maladies mentales - Aspect génétique / Épidémiologie psychiatrique

Cote : WM 100 N974p 2012