Auteur : Hulley, Stephen B. / Cummings, Steven R. / Browner, Warren S. / Grady Deborah / Hearst, Norman

Édition : 2nd edition

Maison d'édition : Lippincott - Williams and Wilkins

Date de publication : 2001

Collation : xv, 336 p. : ill.

ISBN : 0781722187

Langue : Anglais

Table des matières : Section I : Basic ingredients
1. Getting started : the anatomy and physiology of clinical research -- 2. Conceiving the research question -- 3. Choosing the study subjects : specification, sampling and recruitment -- 4. Planning the measurements : precision and accuracy -- 5. Getting ready to estimate sample size : hypotheses and underlying principles -- 6. Estimating sample size and power : the nitt-gritty
Section II : Study designs
7. Designing an observational study : cohort studies -- 8. Designing an observational study : cross-sectional and case-control studies -- 9. Enhancing causal inference in observational studies -- 10. Designing an experiment : clinical trials I -- 11. Designing an experiment : clinical trials II -- 12. Designing studies of medical tests -- 13. Research using existing data : secondary data analysis, ancillary studies and systematic reviews
Section III : Implementation
14. Addressing ethical issues -- 15. Designing questionnaires and data collection instruments -- 16. Data management -- 17. Implementing the study : pretesting, quality control, and protocol revisions -- 18. Community and international studies -- 19. Writing and funding a research proposal

Résumé : It is a pratical guide to planning and implementing clinical research. Straightforward and reader-friendly, this text provides physicians and clinical investigators rigorous and complete descriptions of key components, emphasizing common sense as the main ingredient of good science. The second edition has been greatly strengthened by providing: fresh examples and ideas on what's new in clinical research in every chapter from the first edition, expanded treatment of clinical trial design and implementation, new approaches to sample size estimation, keeping it simple while covering more design options, a major update on ethics and the responsible conduct of research, new chapters on medical test studies, secondary data (including ancillary studies and meta-analysis), data management, and community and international research, new exercices that highlight major clinical research issues

Mots-clés : Études cliniques / Médecine - Recherche / Épidémiologie - Recherche - Méthodologie / Plan d'expérience

Cote : WA 950 H913d 2001