Osteosarcopenia
Duque, Gustavo (Éditeur intellectuel) / Troen, B. R. (Bruce R.) (Éditeur intellectuel)
2022
1 ressource en ligne (xxv, 322 pages) : illustrations
Format PDF
9780128204207
Anglais
1. Muscles and bones -- 2. Cellular senescence and other aging mechanisms in bone and muscle -- 3. Biomechanics and mechanobiology of bone and muscle: Current and future musculoskeletal modeling research directions in osteosarcopenia -- 4. A geroscience approach for osteosarcopenia: Autophagy and senescence as therapeutic targets -- 5. Osteosarcopenia as a lifetime syndrome: Could it be prevented? -- 6. Inflammation and osteosarcopenia -- 7. Sex steroids and gender differences in muscle, bone, and fat -- 8. The role of vitamin D and parathyroid hormone (PTH) in osteosarcopenia -- 9. Falls and fracture risk assessment—The role of osteoporosis, obesity, and sarcopenia -- 10. Osteosarcopenic adiposity -- 11. Diagnosis of osteosarcopenia—Clinical -- 12. Diagnosis of osteosarcopenia—Imaging -- 13. Genetics of osteosarcopenia -- 14. Frailty: The end of the osteosarcopenia continuum? -- 15. Nonpharmacologic intervention for osteosarcopenia -- 16. Pharmacological management of osteosarcopenia -- 17. The social context of osteosarcopenia: Risk factors and social impact -- 18. Models of care for falls and fracture prevention: A historical perspective
Falls, fractures, frailty, osteoporosis and sarcopenia are highly prevalent in older persons. While the concept of osteosarcopenia is new, it is a rapidly evolving and cross-disciplinary problem. Prevention and treatment are challenging and a combined therapeutic approach is needed. Osteosarcopenia provides evidence-based information on how to prevent and treat these conditions at multiple settings, including multiple illustrations, care pathways and tips to easily understand the pathophysiology, diagnostic methods and therapeutic approach to these conditions. This work evaluates the potential for a link between osteoporosis, sarcopenia and obesity. Key Features: Presents diagnostic and therapeutic tips that facilitate the design and implementation of new care pathways, impacting the wellbeing of our older population. Provides cross-disciplinary understanding by experts from the bone/osteoporosis field and the muscle/sarcopenia field. Covers muscle and bone biology, mesenchymal stem cells, age-related changes and cross-talk between muscle, fat and bone, falls and fracture risk, glucose metabolism, diagnosis, imaging, and genetics of osteosarcopenia.
Ostéoporose / Appareil locomoteur - Maladies / Muscles - Maladies / Vieillissement - Aspect physiologique