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Psychiatric Genetics : applications in clinical practice Smoller, Jordan W. ; Sheidley, Beth Rosen ; Tsuang, Ming T. | American Psychiatric Publishing 2008

- xiii, 323 p. : ill.
Cote : WM 140 S666p 2008

Maladies mentales - Aspect génétique ; Conseil génétique

Psychiatric Genetics is the first book to focus on clinical applications of genetics in psychiatry. It covers issues involved in genetic counseling, the interpretation of familial and genetic information for clinical use, information regarding risks associated with specific psychiatric disorders, and the uses of genetic testing. Written explicitly for practitioners, it offers a clinically relevant resource to help readers interpret the often bewildering flood of information about genetics and to facilitate responding to patients requests to predict the risk of recurrence of psychiatric illness or provide information about reproductive and pregnancy-related issues.

The book first presents a framework for understanding and critically evaluating psychiatric genetic research literature, then provides guidelines for genetic counseling. Subsequent chapters summarize genetic aspects of major psychiatric conditions from childhood-onset disorders through psychotic, mood, and anxiety disorders to dementia as well as neuropsychiatric manifestations of other genetic disorders. Risk/benefit considerations related to medication use during pregnancy are then presented. Coverage of ethical, legal, and social implications illustrates the dilemmas that arise with advances in genetic research. Whether used as a clinical guide, reference, or ancillary text, Psychiatric Genetics provides the most up-to-date source on the impact of this growing field on everyday psychiatric practice.

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Early clinical intervention and prevention in schizophrenia Stone, William S. ; Faraone, Stephen V. ; Tsuang, Ming T. | Humana Press 2004

- xiv, 374 p. : ill. + 1 CD-ROM
Cote : WM 203 S881e 2004

Schizophrénie

Although much work remains to be done toward understanding the causes of schizophrenia and attenuating its symptoms, a clear consensus has emerged that better outcomes are associated with early treatment. In Early clinical intervention and prevention in schizophrenia, leading and internationally recognized researchers review what is know about the liability to schizophrenia, how it progressesm what it looks like clinically, with an emphasis on a specific (proposed) syndrome of liability (schizotaxia), and how best it might be treated now and in the near future. The authors summarize the latest findings on the genetic, early environmental, and neurodevelopmental origins of schizophrenia, and detail the nature of the vulnerability to schizophrenia from several perspectives, including the prodrome and their proposed pre-prodromal syndrome of schizotaxia. Specific factors, such as cognitive deficits in high-risk populations, neuroanatomical abnormalities, and psychophysiological deficits are also considered. From this material, the contributors develop protocols fot eh treatment of schizotaxia and prodromal symptoms, and discuss issues related to genetic counseling. Thay also explore the neurochemical and molecular possibilities for advancing the goals of prevention and early intervention in schizotaxia. Timely and cutting-edge, Early clinical intervention and prevention in schizophrenia offers psychologists, psychiatrists, and neurologists an authoritative account of how the liability to develop schizophrenia is expressed in meaningful, measurable ways that can provide a basis for early intervention and preventive efforts.

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Recognition and prevention of major mental and substance use disorders Tsuang, Ming T. ; Lyons, Michael J. ; Stone, William S. | American Psychiatric Publishing 2006

- xvii, 411 p.
Cote : WM 140 R311 2006

Maladies mentales - Prévention ; Toxicomanie - Prévention

Recognizing that favorable clinical outcomes are associated with earlier initiation of treatment--and even more ideally with prevention--this volume addresses the current status of early intervention in, and prevention of, major mental and substance use disorders. A team of distinguished participants addresses this problem at many levels--from the DNA molecule to public policy--in order to show how prevention efforts should be informed by a better understanding of etiology and by a knowledge of indicators of vulnerability.

In considering the current standing of etiological knowledge, Recognition and Prevention of Major Mental and Substance Use Disorders addresses issues that are critical precursors to the prevention of mental disorders and offers an understanding of factors that contribute to the disorders' development. The contributors review genetic methodologies and current findings in mental disorders, with an emphasis on schizophrenia, and then show how biological and psychosocial environmental variables may affect vulnerability. Chapters devoted specifically to lessons in prevention drawn from recent research into schizophrenia discuss the implications of prodromal studies and relationships between stress, critical periods, and the development of the disorder. The book includes contributions from NIH representatives on how basic scientific understanding of mental disorders can be translated into public policy. It also features chapters that describe cutting-edge projects in prevention research for Alzheimer's disease, drug dependence, antisocial behavior, and posttraumatic stress disorder--each providing compelling accounts of how existing knowledge can be adapted to promising prevention efforts. Among the volume's contributions: - New data on the role of substance abuse--particularly marijuana and psychostimulants--in increasing vulnerability to schizophrenia- Review of vulnerability factors for several relevant disorders, examining stress and its concomitant psychobiological responses and the contribution of cognitive factors to vulnerability to depression- Intriguing approach for translating successful treatment methods for schizophrenia into efforts to prevent the transition from the prodrome of the disorder to the full-blown illness- Program for prevention of antisocial behavior that can be implemented as early as the first grade- Secondary prevention efforts for posttraumatic stress disorder, with a focus on pharmacological interventions

Each chapter reviews clinical implications of the research presented, contributing to a volume that will benefit clinicians and researchers who share the goal of preventing these debilitating conditions. This multidimensional, interdisciplinary work represents a major step toward cutting the social costs of these disorders--and, more important, their untold cost in human suffering.

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